Supplemental materials

Rotavirus vaccination reduces the incidence and severity of acute gastroenteritis due to rotavirus infection. However, because of a lack of understanding and private payment for the rotavirus vaccine, the rotavirus vaccination rate is still low in some countries. To assess the impact of shared decision-making (SDM) with the assistance of patient decision aids (PDAs) on the rotavirus vaccination rate, and the knowledge, confidence, and congruence of value among baby’s parents when decision-making. The study was a two-group, outcome assessor-blind, randomized, controlled trial. The families of 1-month-old infants for routine vaccination were enrolled; they were divided randomly into non-SDM and SDM groups. The influence of SDM on the acceptance of rotavirus vaccination was assessed when they were 2 months old. Outcome measures were decisional conflict, decision-making difficulties, and rotavirus vaccine knowledge, and the overall rotavirus vaccination rate. The study enrolled 180 participants. SDM, parents’ education level, and rotavirus vaccination of a previous child were variables that influenced acceptance of rotavirus vaccination. The SDM group scored significantly higher for understanding the information on the oral rotavirus vaccine than the non-SDM group, which helped them to decide whether to vaccinate the baby against rotavirus. The rotavirus vaccination rate was 16.7% higher in the SDM group than the non-SDM group. SDM assisted with PDAs gives more information and helps infants’ families understand what they need, reduces their decision conflict, and increases their baby’s vaccination against rotavirus, which promotes public health. The clinical trial is registered at ClinicalTrials.gov (NCT03804489).

HN RCT

Supplemental Figure 1. AVF created by aortocaval puncture. Supplemental Figure 2. Doppler signals for confirmation of successful AVF creation. Supplemental Figure 3. Non-specific staining control. Supplemental Figure 4. Non-specific control of anti-ITGB6 antibody. Supplemental Table 1. Reference of the antibodies used in western blots Supplemental Table 2. Demographic and laboratory characteristics and risk for AVF maturation failure tested by univariable logistic regression. Supplemental Table 3. Medication and risk for AVF maturation failure tested by univariable logistic regression.

All-cause mortality rates are adjusted by sex and 5-y age groups. (Data from Taiwan Ministry of the Interior. Statistical Data Query. Accessed at https://statis.moi.gov.tw/micst/stmain.jsp?sys=100 on 12 January 2021.) Middle. Pneumonia and influenza mortality rates, including bacterial, viral, and unspecified pneumonia, are adjusted by 3 age groups (0 to 49, 50 to 64, and ≥65 y). (Data from Taiwan Centers for Disease Control. Taiwan National Infectious Disease Statistics System. Accessed at https://nidss.cdc.gov.tw/en/Default.aspx on 12 January 2021.) Bottom. Road traffic mortality rates (occurred within 30 d from the accident) are adjusted by 3 age groups (0 to 24, 25 to 64, and ≥65 y). (Data from Taiwan Ministry of Transportation and Communications. Commonly used transportation statistics. Accessed at https://stat.motc.gov.tw/mocdb/stmain.jsp?sys=100&funid=emenu on 12 January 2021.)

Background: No consensus exists on the appropriate timing of adjuvant radiotherapy administration after surgical excision of keloids. Objective: This study investigated the appropriate timing of adjuvant radiotherapy. Methods: A systematic review and meta-analysis of randomized controlled trials and observational cohort studies were performed. A pooled estimate of the incidence rate was performed using a random-effect model. Subgroup analyses based on different anatomic regions, biological effective dose, keloid length, and radiotherapy regimen were also conducted. Results: Sixteen observational cohort studies (1908 keloid lesions) met the inclusion criteria. The incidence rate was significantly reduced in the group treated more than 24 h after surgery (3.80%; 95% CI: 1.78% to 8.13%) compared with the group treated within 24 h (37.16%; 95% CI: 20.80% to 66.37%) (P < .0001) with electron beam therapy but was not significantly different between the groups with brachytherapy and X-ray treatment. Limitations: Most of the included studies were single-arm nonrandomized observational studies. Therefore, randomized controlled trials are warranted to validate the appropriate timing of postoperative radiotherapy. Conclusion: Immediate adjuvant radiotherapy led to no significant reduction in the incidence rate of recurrent keloids

HNSCC of TCGA, combining clinical and RNA-Seq dataset (with the feature of tobacco exposure)

Substitution of cobalt for calcium in hydroxyapatite resulted in CoHA with a higher effective atomic number. This study evaluated various medical imaging characteristics of round CoHA ingots in porcine phantom to demonstrate the feasibility of using CoHA ingots as a radiotherapy marker. CoHA was compressed into round ingots and then implanted into phantom of porcine liver and gelatin phantom of porcine vertebra along with three commercially available radiotherapy markers. The phantom were scanned and photographed using a routine x-ray imager, magnetic resonance imager, computed tomography (CT) imager, and ultrasound imager, respectively, followed by image analysis in ImageJ software. CoHA ingots could be clearly identified with general imaging instruments (X-ray, CT, and ultrasound) and the image size did not change. There were some metal artifacts in the magnetic resonance images. CoHA ingots can be used with most medical imaging instruments to help quickly identify the location and extent of soft-tissue tumors, and are biodegradable, that is, they can be self-absorbed by the body over time to avoid interference with follow-up disease screening

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